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Why Is Nattokinase in Boostaro, and Why Do Doctors Ask About It?

Medically reviewed by Dr. Rachel Rubin, MD, Physician

Earnings disclosure: this website earns when an order goes through its checkout. It is a USA Authorized Boostaro Retailer, not the manufacturer.

What is nattokinase, and where does it come from?

Natto is a Japanese dish made from soybeans that have been fermented with a bacterium. Nattokinase is an enzyme that scientists isolated from that dish. It is not the food itself. It is one protein pulled out of it and, in a supplement, packed into a capsule.

On the Boostaro panel it is the seventh and last named ingredient. The sales page this website works from lists it by name only. There is no weight and no strength printed beside it.

That one missing detail matters more for an enzyme than for a vitamin. A vitamin is weighed. An enzyme is measured by what it does, and that measure has its own unit. We come back to that in the next section.

Why are enzymes measured in units instead of milligrams?

A milligram tells you how heavy something is. It does not tell you how active it is. Two enzyme powders of the same weight can differ a lot in strength, based on how they were made and how long they sat on a shelf.

For nattokinase, the unit that matters is the fibrinolytic unit. Fibrinolytic means able to break down fibrin, which is a protein that helps hold a clot together. A label that gives the activity in those units tells you what you are really getting.

The Boostaro papers give neither number. There is no milligram figure and no fibrinolytic unit figure. Because of that, nobody can say if one capsule holds a small, medium or large dose of the enzyme. We would rather print that gap than guess.

If a bottle ever arrives with a figure in fibrinolytic units, send a photo to the website desk. This page will be corrected and the review date will move forward.

What did the main nattokinase trial find?

The trial most often quoted is by Kim and colleagues, published in 2008. It was a randomised, controlled trial. A review by Chen and colleagues in 2018 later gathered the background science on how the enzyme might act.

Read the table from left to right. The trial answers a question about blood pressure in people who already had raised readings. Boostaro is sold for adult men with a blood flow line on the bottle. The people, the goal and the dose are all different.

That does not make the result worthless. It means the number should stay with the trial. It cannot be moved onto a capsule whose strength is unknown.

Which medicines make nattokinase a question for the prescriber?

Nattokinase has fibrinolytic activity. Because of that, it can add to the effect of medicines that thin the blood or stop platelets from clumping. The safety page on this website names the main ones.

Do not guess. A pharmacist can check your whole list in a few minutes, and many will do it for free. Take the bottle with you, or a clear photo of the label.

Does nattokinase matter if you have a soy allergy?

Yes, it can. The safety page notes that nattokinase is derived from fermented soy. A person with a known soy allergy should ask a clinician before taking any product that names it.

An allergic reaction to a supplement is rare, but it is a reason to stop at once and seek medical help. Signs include a rash, swelling of the lips or face, or trouble breathing. Do not wait for the refund window to decide. Your health comes first, and the order desk will deal with the return afterwards.

Even if you have never had a soy problem, read the full label when the bottle arrives. The label on the bottle is the final word on what is inside.

Should you stop nattokinase before surgery?

The usual advice is yes, and the site’s own safety table says so in plain words: it is usually stopped before surgery. How far ahead is a question for the surgical team, and the material we hold does not give a number of days. So we do not print one.

Tell the team about Boostaro at the first planning visit, not on the morning of the operation. Say that it contains nattokinase and vitamin K2, and mention the pine bark too. Dental work counts as well, since some procedures involve bleeding.

A separate article on this website walks through the questions to ask before a procedure. For now, remember the simple rule. If anything is booked, ask first.

How should you judge a capsule that hides its enzyme strength?

You judge it by what you can check. You can check the lot code on the base of the bottle. You can check the seal under the cap. You can check the 60-day window and the phone desk. You cannot check the activity of the enzyme.

That leaves a personal test. Take it as the label directs, write a short weekly note, and compare week six with week one. The distributor’s summary puts reported change at three to six weeks, and buyers who wrote at day 30 or later give a calmer picture than the one who wrote at day 17.

If you notice easy bruising, bleeding that is hard to stop, or any other sign that worries you, stop and call a clinician. Nothing here is a treatment for any disease, and a supplement is never a replacement for your medicine.

Frequently asked questions

Our view

Nattokinase is the ingredient on this panel that is most likely to matter to a prescriber. That is not a mark against the product. It is simply a fact about what the enzyme does, and a fair page puts it near the top.

The missing figures make it harder. With no strength printed, a buyer cannot compare the capsule with the trial, and a doctor cannot judge how much to worry. Until a figure is published, treat it as a medicine-level question and ask before you start.

If you take no relevant drug and have no procedure planned, the 60-day window still gives you time to try it and judge for yourself.

Earnings disclosure: this website earns when an order goes through its checkout. It is a USA Authorized Boostaro Retailer, not the manufacturer.